EPP124
Diminishing Loss Sensitivity during Risky Decision-Making among Individuals with Gambling Disorder
H. Wei 1, G. Zhong 1, J. Liu 1, Y. Wei 1, X. Zhang 1, P. Yang 1, M. Zhao 1 2, J. Du 1,*
1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 2Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai, China
Introduction: Gambling disorder (GD) poses severe impacts on both individuals and society. Impairment in risky decision-making is a key behavioral characteristic of GD, but the underlying cognitive processes of these deficits remain unclear.
Objectives: This study decomposed the risky decision-making processes of GD with cognitive computational modeling.
Methods: A total of 100 participants with GD and 59 healthy controls (HCs) were recruited to complete psychometric assessments and the Balloon Analog Risk Task. Since GD involved abnormal loss evaluation in decision-making, we developed a novel cognitive model incorporating diminishing loss sensitivity and revealed the processes underlying the risk-taking behaviors with hierarchical Bayesian analysis.
Results: GD participants exhibited stronger loss aversion (p < 0.001) but faster-diminishing loss sensitivity (p < 0.001), regardless of severity, which drove the deficits in the overall performance of risky decision-making (p < 0.001) (Fig1). Overconfident prior belief (p = 0.002) and higher updating rate (p < 0.001) were observed among participants with GD (Fig3). Diminishing loss sensitivity was negatively correlated with impulsivity (p = 0.021), and loss aversion was negatively related to craving for gambling (p = 0.027) (Fig4).
Table 1. Demographic and clinical characteristics of participants.
Characteristic |
Total, N = 159 |
HC, n = 59 |
GD, n = 100 |
F/H |
p |
Effect Size |
|
Age, Years |
30.84 ± 7.91 |
31.71 ± 9.91 |
30.33 ± 6.45 |
H1 = 0.28 |
0.595 |
η2 = 0 |
|
Education, Years |
14.96 ± 3.25 |
15.27 ± 4.49 |
14.77 ± 2.23 |
H1 = 2.57 |
0.109 |
η2 = 0.010 |
|
BIS Score |
82.78 ± 17.64 |
69.20 ± 16.04 |
90.79 ± 13.09 |
F1, 157 = 85.127 |
< 0.001 |
η2 = 0.352 |
|
VAS Score |
|
|
3.65 ± 3.34 |
|
|
|
HC: Health controls; GD: Gambling disorder; BIS: Barret Impulsivity Scale; VAS: Visual Analog Scale for gambling craving.
Table 2. Demographic and clinical characteristics of subgroups of participants.
Characteristic |
Total, N = 159 |
HC, n = 59 |
Mild&Moderate, n = 46 |
Severe, n = 54 |
F/H |
p |
Effect Size |
|
Age, Years |
30.84 ± 7.91 |
31.71 ± 9.91 |
30.78 ± 5.86 |
29.94 ± 6.95 |
H2 = 1.48 |
0.476 |
η2 = 0 |
|
Education, Years |
14.96 ± 3.25 |
15.27 ± 4.49 |
14.93 ± 1.84 |
14.63 ± 2.52 |
H2 = 2.60 |
0.273 |
η2 = 0.004 |
|
BIS Score |
82.78 ± 17.64 |
69.20 ± 16.04 |
88.50 ± 13.99 |
92.74 ± 12.07 |
F2, 156 = 44.001 |
< 0.001 |
η2 = 0.361 |
|
VAS Score |
|
|
3.07 ± 3.01 |
4.15 ± 3.55 |
H1 = 2.00 |
0.158 |
η2 = 0.010 |
HC: Health controls; Mild&Moderate: Mild and moderate gambling disorder participants; Severe: Severe gambling disorder participants; BIS: Barret Impulsivity Scale; VAS: Visual Analog Scale for gambling craving.
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Conclusions: This research provides novel perspectives on the cognitive processes underlying the risky decision-making of GD patients, highlighting the role of diminishing loss sensitivity during loss evaluation and its clinical implications, which inspires future research on assessment and psychotherapy for GD.
Disclosure of Interest: None Declared